1301 Polyamines: Novel regulators of human epidermal pigmentation

The purpose of this study was to understand the impact altered polyamine levels on epidermal pigmentation. We used laser-capture microscopy and human primary melanocyte culture establish mechanisms by which polyamines function significance their misregulation in Melasma. are ubiquitously expressed cations that essential for a wide array cellular events. Changes intracellular can have regulatory role cells through control gene expression protein function. show regulator ODC1 is increased melanocytes isolated laser capture from melasma lesional compared non-lesional skin. Increased promotes we putrescine promote TYR activity melanogenesis skin organ cultures. Elevated drive an increase catabolism SAT1 SMOX. This turn results production H202 propose, part, drives melanogenesis. When inhibited treated cells, no longer activated pigment decreased. identified number specific inhibitors block induced pigmentation Polyamine response UV exposure, wounding inflammation. Our data suggests sensitive changes extracellular respond modulating production. disclose interesting relationship between could enhance our understanding not only normal melanogenesis/ melanin transfer but also pigmentary disorders.